Yazar "Çakıcı, Çağrı" için listeleme
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1,25(OH)2D3 vitaminin apopitoz ve oksidatif stres üzerine doza bağlı etkileri
Çakıcı, Çağrı (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2016)Bu çalışmanın amacı1,25(OH)2D3 vitamininin apopitoz ve oksidatif stres üzerine doza bağlı etkilerini araştırmaktır. İstanbul Medipol Üniversitesi Rejeneratif ve Restoratif Tıp Araştırmaları Merkezinde (REMER) yapılan ... -
Can lactate dehydrogenase inhibition be increased efficiency of 1,25(OH)2 D3 vitamin in prostate cancer animal model?
Çakıcı, Çağrı; Daylan, Benay; Ayla, Şule; Yiğit, Pakize; Yavuz Dokgöz, Elif; Yigitbaşı, Türkan (NLM (Medline), 2022)The Warburg effect explains that the cancer cell's metabolism is programmed based on anaerobic glycolysis to support the proliferation and anabolic growth of cancer cells. LDH-A is the form of LDH found in cancer cells, ... -
Chronic unpredictable stress disturbs the blood-testis barrier affecting sperm parameters in mice
Kolbaşı, Bircan; Bülbül, Muhammet Volkan; Karabulut, Seda; Erdem Altun, Ceren; Çakıcı, Çağrı; Ülfer, Gözde; Müdok, Tangül; Keskin, İlknur (Elsevier Ltd, 2021)Research question: Does chronic stress affect the key proteins and sperm parameters of the blood & ndash;testis barrier (BTB)? Design: C57Bl/6 mice were divided into two groups: a non-treated control group and a chronic ... -
Could the increase in oxidative stress be the reason for the increased polyamine levels in diabetic obese and non-diabetic obese patients?
Göktürk, Nurcan; Şahin, Hicret; Bayramoğlu, Feyza; Çakıcı, Çağrı; Büyükuslu, Nihal; Yiğit, Pakize; Yiğitbaşı, Türkan (İstanbul Medipol University, 2022)Putresin, spermine, and spermidine are important polyamines found in all living organisms. In this study, as a first in the literature, we aimed to investigate polyamines levels and their relationship with oxidative stress ... -
The creation of unilateral intermittent and unintermittent renal ischemia-reperfusion models in rats
Soytaş, Mustafa; Gürsoy, Duygu; Boz, Mustafa Yücel; Çakıcı, Çağrı; Keskin, İlknur; Yiğitbaşı, Türkan; Güven, Selçuk; Horuz, Rahim; Albayrak, Selami (Wolters Kluwer Medknow Publications, 2021)Background and Aim: This study aims to establish unilateral intermittent and unintermittent partial nephrectomy-like renal ischemia-reperfusion (I-R) model in rats and to compare the results with biochemical findings. ... -
Demir eksikliği anemisi olan ve olmayan bireylerde serum sialik asit düzeyleri
Ülfer, Gözde; İstanbullu Tosun, Ayşe; Olmuşçelik, Oktay; Yiğitbaşı, Türkan; Çakıcı, Çağrı; Bayramoğlu, Feyza; Emekli, Nesrin (2017)Amaç: Bu çalışmanın amacı demir eksikliği anemisi (DEA) parametreleri ile serum total sialik asit (SA) değerleri arasındaki ilişkinin incelenmesidir. Yöntemler: Çalışmada DEA olan 30 hasta ve 30 sağlıklı kişide serum total ... -
Deneysel prostat kanserinde tümör metabolizmasının laktat dehidrojenaz ilişkili değişiminin apoptoz ve epitelyal mezenkimal dönüşüm (EMT) üzerindeki rolü
Çakıcı, Çağrı (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2021)Çalışmamızda oluşturulan deneysel prostat kanser modelinde LHD-A inhibitörünün 1,25(OH)2D3 vitamini ve Dosetaksel ile kombinasyonunun apoptoz, oksidatif stres ve EMT mekanizmaları üzerine etkilerinin araştırılması ... -
Design of IKVAV peptide/gold nanoparticle decorated, micro/nano-channeled PCL/PLGA film scaffolds for neuronal differentiation and neurite outgrowth
Aydeğer, Asel; Ayşit, Neşe; Baydaş, Gülsena; Çakıcı, Çağrı; Erim, Ümit Can; Arpa, Muhammet Davut; Özçiçek, İlyas (Elsevier Ltd, 2023)In the field of neural tissue engineering, intensive efforts are being made to develop tissue scaffolds that can support an effective functional recovery and neural development by guiding damaged axons and neurites. ... -
Dose-dependent effects of vitamin 1,25(OH)2D3 on oxidative stress and apoptosis
Çakıcı, Çağrı; Yiğitbaşı, Türkan; Ayla, Şule; Karimkhani, Hadi; Bayramoğlu, Feyza; Yiğit, Pakize; Kılıç, Ertuğrul; Emekli, Nesrin (Walter de Gruyter GmbH, 2018)The purpose of this study is to examine the dose-dependent effects of vitamin 1,25(OH)2D3 on apoptosis and oxidative stress. In this study, 50 male Balb/c mice were used as control and experiment groups. The mice were ... -
The effects of gold nanoparticles with different surface coatings and sizes on biochemical parameters in mice
Özçiçek, İlyas; Çakıcı, Çağrı; Ayşit, Neşe; Erim, Ümit Can (Prusa Medical Publishing, 2023)Objectives: Gold nanoparticles are very popular metallic nanomaterials and they have a wide spectrum of biomedical applications. This study was aimed to the production of stable and monodisperse polyethyleneimine (PEI) and ... -
The effects of size, shape and surface functionality on in vivo biodistribution and toxicity: A multiparametric biochemical study of gold nanomaterials
Özçiçek, İlyas; Altuncu, N.; Çakıcı, Çağrı; Aydeğer, Asel (Wiley, 2021)Gold nanomaterials have a widespread use due to their superior physical and chemical properties. Gold nanoparticles and nanorods are very popular and stable metallic nanomaterials which can be synthesized easily in various ... -
The effects of surface functionality and size of gold nanoparticles on neuronal toxicity, apoptosis, ROS production and cellular/suborgan biodistribution
Özçiçek, İlyas; Ayşit, Neşe; Çakıcı, Çağrı; Aydeğer, Asel (Elsevier B.V., 2021)Gold nanoparticles are emerging as promising nanomaterials to create nanoscale therapeutic delivery systems. The aim of the study was to synthesis of highly monodisperse and stable gold nanoparticles functionalized with ... -
The effects of various surface coatings of gold nanorods on toxicity, neuronal localization, microstructural alterations, and in vitro/in vivo biodistribution
Özçiçek, İlyas; Ayşit, Neşe; Çakıcı, Çağrı; Ulaş Aytürk, Nilüfer; Aydeğer, Asel; Erim, Ümit Can (Wiley, 2022)With the development of gold nanorods (AuNRs) for a number of biomedical applications, understanding their various biological effects has become important. Surface functionalization of AuNRs is attracting increasing attention ... -
The importance of antioxidant status in gastric intestinal metaplasia
Danış, Nilay; Ertınmaz Özkan, Ayşegül; Karataş, Fatih; Çakıcı, Çağrı; Yiğitbaşı, Türkan; Özkan Sevencan, Nurhayat; Kayhan, Burçak (Society of Medical Biochemists of Serbia, 2021)Background: Oxidative stress status in different cancer types was investigated before, but not studied in gastric intestinal metaplasia to the best of our knowledge. Purpose of this study is to examine whether there is a ... -
Investigation of coenzyme Q10 levels and predisposing factors in patients with striae gravidarum
Yüksel, Mavişe; Lebriz Aktün, Hale; Balevi, Ali; Çakıcı, Çağrı; Ülfer, Gözde (Wiley, 2020)Background: Striae gravidarum (SG) can cause pregnant women severe psychological stress. Objective: This study aimed to compare primigravidas with and without SG concerning fasting blood coenzyme Q10 (CoQ10), age, skin ... -
Large-scale proteomic analysis of patients with type 2 diabetes mellitus and atherosclerosis using a label-free LC-MS/MS approach
Sürmen, Mustafa Gani; Alkan Bozkaya, Tijen; Ateş, Mehmet Şanser; Sürmen, Saime; Çakıcı, Çağrı; Pençe, Sadrettin; Emekli, Nesrin (Istanbul University, 2023)Objective: Type 2 diabetes mellitus (T2D) is a metabolic disease whose molecular events have not yet been fully clarified. However, next-generation powerful molecular approaches such as mass spectrometry (MS)-based proteomics ... -
LDH-A inhibitor as a remedy to potentiate the anticancer effect of docetaxel in prostate cancer
Çakıcı, Çağrı; Daylan, Benay; Ünlüer, Rüveyde Safiye; Emekli Alturfan, Ebru; Ayla, Şule; Eren Gözel, Hilal; Yiğit, Pakize; Yavuz Dokgöz, Elif; Yiğitbaşı, Türkan (Ivyspring International Publisher, 2024)Increased LDH-A activity promotes tumor growth, migration, invasion, and metastasis. This study aimed to investigate the effects of the combination of LDH-A inhibitor and Docetaxel on apoptosis and epithelial-mesenchymal ... -
Relationship between interleukin 33 and tissue factor in non-diabetic and diabetic obese patients
Çakıcı, Çağrı; Yiğitbaşı, Türkan; Alagöz, Maide Hacer; Yiğit, Pakize; Emekli, Nesrin (Istanbul Medipol University, 2021)The aim of the study is to investigate the relationship between tissue factor (TF) and Interleukin-33 (IL-33) and biochemical parameters in diabetic obese and non-diabetic obese patients. 21 healthy controls, 25 non-diabetic ... -
The relationship between zonulin and metabolic syndrome in renal transplant patients
Canbaloğlu Erkan, Gülbanu; Şumnu, Abdullah; Ertuğrul, Gökhan; Ülfer, Gözde; Çakıcı, Çağrı; Aydın, Hüseyin Çağatay; Ünal, Aydın (Verlag Klinisches Labor GmbH, 2023)Background: Levels of zonulin, a surrogate marker of intestinal permeability, are elevated in various disorders including insulin resistance, obesity, celiac disease, and inflammatory bowel disease. We aimed to elucidate ... -
The role of makorin ring finger protein-3, kisspeptin, and neurokinin B in the physiology of minipuberty
Atay, Enver; Kılınç, Suna; Ülfer, Gözde; Yiğitbaşı, Türkan; Çakıcı, Çağrı; Turan, Murat; Ceran, Ömer; Atay, Zeynep (Walter de Gruyter GmbH, 2021)Background: There is no data regarding the interrelationships of circulating Makorin Ring Finger Protein-3 (MKRN3), Kisspeptin (KISS1), and Neurokinin B (NKB) concentrations during minipuberty in humans.Objective: To ...